HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → HCID 18794222, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | HCID 178487038 | HCID 178487038 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 18794222 | HCID 18794222 | 20% |
Reaction Steps
To a solution of 10-methoxyharmalan (40 mg) in triethylamine (1 ml) is added TFA (2.2 eq). After reaction for 15 min. at 0° C., the mixture is hydrolysed and extracted with CH2Cl2. The crude product is then chromatographed on a preparative plate (eluent: CH2Cl2). 1-Methylene-2-trifluoroacetyl-6-methoxy-1,2,3,4-tetra-hydro-β-carboline is recovered (yield: 20%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06048868 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-a539d09935db42fb9cac7bada0e57245 |
| Source note | uspto-grants-2000_04 |