Acetic Anhydride → HCID 18794226, compound

Participants

Reaction Conditions

Reaction Steps

To acetic anhydride (1 ml) cooled to 0° C. is added dropwise formic acid (0.5 ml). The mixture is heated for 15 min. at 50° C. After cooling rapidly to 0° C., 10-methoxyharmalan (200 mg) is added slowly and portionwise and the medium is left stirring for 2 h. The crude product is then taken to dryness and, after separation by chromatography (eluent: EtOAc/pet. ether; 50/50), 1-methylene-2-formyl-6-methoxy-1,2,3,4-tetrahydro-β-carboline is obtained.

Provenance & Evidence