Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | HCID 178487038 | HCID 178487038 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 18794251 | HCID 18794251 | — |
Reaction Steps
To a solution of 10-methoxyharmalan in dichloro-methane is added triethylamine (1.5 eq) and the mixture is cooled to 0° C. A solution (1/5 v/v) of ethyl chloro-formate in dichloromethane is then added dropwise. The mixture is stirred at 0° C. until the starting material disappears (2 h). After evaporation of the solvent, the crude product is separated out on a chromatography plate (eluent: EtOAc/pet. ether; 50/50).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06048868 |
|---|
| Source dataset | uspto-grants-2000_04 |
|---|
| ORD ID | ord-f5fdb552537747b6af0f5e7b9a92e04b |
|---|
| Source note | uspto-grants-2000_04 |
|---|
