HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 1-(1-Methylidene-1,3,4,9-tetrahydro-2H-beta-carbolin-2-yl)ethan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | HCID 178421669 | HCID 178421669 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-(1-Methylidene-1,3,4,9-tetrahydro-2H-beta-carbolin-2-yl)ethan-1-one | HCID 13795031 | — |
Reaction Steps
To a solution of harmalan (1 mmol) in pyridine (2 ml) is added acetic anhydride (1.1 eq). After acid hydrolysis and extraction with ethyl acetate, the crude product is flash-chromatographed (eluent: EtOAc/pet. ether; 50/50). The 1-methylene-2-acetyl-1,2,3,4-tetrahydro-β-carboline elutes off first.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06048868 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-575cea39bea6408b88fee262c486e284 |
| Source note | uspto-grants-2000_04 |