HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methoxytryptamine → 9-Methoxy-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methoxytryptamine | HCID 1833 | — |
| Reactant | Diethyl glutarate | HCID 13163 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 9-Methoxy-2,3,4,6,7,12-hexahydroindolo[2,3-a]quinolizin-4-one | HCID 18794212 | — |
Reaction Steps
A mixture of 5-methoxytryptamine (420 mg) and diethyl glutarate (460 mg) is heated at 175° C. for 18 h. eparation on a column (eluent: EtOAc) gives the amide ster 2. This product is treated with a trace of ara-toluenesulphonic acid in xylene and the water formed is removed using Dean-Stark apparatus. After refluxing for 9 h and separation on a silica plate, N-[2-(5-methoxy)indol-3-ylethyl)]glutarimide is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06048868 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-fef6b6529bbb4929a6e7031e4277a965 |
| Source note | uspto-grants-2000_04 |