Ethyl chloroformate → ethyl 2-acetyl-6-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-beta-carboline-9-carboxylate

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Reaction Steps

Sodium hydroxide (3 g), tetrabutylammonium hydrogen sulphate (1.87 g) and ethyl chloroformate (2.2 mL) are successively added to a solution of 1-(6-methoxy- 1-methyl-2,3,4,9-tetrahydro-1H-β-carbolin-2-yl)-1-ethanone (1.45 g) in dichloromethane (100 mL). The mixture is stirred at room temperature for 3 h. After separation on silica gel (chloroform/methanol eluent), the ethyl 2-acetyl-6-methoxy-1 -methyl-2,3,4,9-tetrahydro-1H-β-carboline-9-carboxylate is obtained (70% yield).

Provenance & Evidence