Lawesson's reagent → 1-(6-methoxy-1-methyl-2,3,4,9-tetrahydro-1H-betacarbolin-2-yl)-1-ethane-thione

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Reaction Steps

Lawesson's reagent (520 mg) is added portionwise, at 110° C., to a solution of 1-(6-methoxy-1-methyl-2,3,4,9-tetrahydro- 1H-β-carbolin-2-yl)-1 -ethanone (500 mg) in anhydrous toluene (25 mL). After refluxing for 1 h and evaporation of the toluene, the product is chromatographed on silica gel (99/1 chlorofomvmethanol eluent) and the 1-(6-methoxy-1-methyl-2,3,4,9-tetrahydro- 1H-β-carbolin-2-yl)-1 -ethanethione is thus recovered (40% yield).

Provenance & Evidence