HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Methyl 2-(2-chloro-4-nitrophenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Dimethyl 2-(2-chloro-4-nitrophenyl)malonate | HCID 11414995 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 2-(2-chloro-4-nitrophenyl)acetate | HCID 21876245 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
2-(4-nitro-2chlorophenyl)-malonic acid dimethyl ester was dissolved in DMSO, then lithium chloride (0.759 g), and water (0.15 mL) were added. The mixture was heated to 100° C. for 3h. The reaction was cooled and the product purified by chromatography on silica gel eluting with hexane/ethyl acetate (9:1) to give the title compound as a yellow oil (1.77 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06048872 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-f0c2225275164f4ab65e349585c6cc64 |
| Source note | uspto-grants-2000_04 |