(4-Nitro-2,6-difluoro-phenoxy)-acetic acid methyl ester → Methyl (4-amino-2,6-difluorophenoxy)acetate

Participants

Reaction Steps

A slurry of (4-nitro-2,6-difluoro-phenoxy)-acetic acid methyl ester (737 mg, 2.98 mmol) and 10% palladium on carbon (200 mg) in tetrahydrofuran (40 mL) was stirred under 1 atmosphere of hydrogen gas for 7 h. The mixture was flushed with nitrogen, and filtered through a pad of celite to afford the title compound as a pale tan oil (646 mg) that solidified on standing.

Provenance & Evidence