Sodium Hydroxide → HCID 9910967, compound

Participants

Reaction Conditions

Reaction Steps

The above ester (4.75 g, 10.5 mmol) was dissolved in ethanol (40 ml) and 5 N sodium hydroxide (5 ml) was added. The mixture was stirred at 40° C. for 20 h, ethanol was evaporated in vacuo and water (50 ml) followed by acetic acid (4 ml) were added. The mixture was extracted with dichloromethane (100 ml), the organic phase was dried (MgSO4) and the solvent was evaporated in vacuo. The residue was crystallised from diethyl ether to give 2.2 g (45%) of the title compound as a solvate with water and acetic acid.

Provenance & Evidence