Hydrochloric Acid → HCID 19261396, compound

Participants

Reaction Steps

The above ester was dissolved in ethyl acetate and the solution was treated with gaseous hydrogen chloride at 0° C. for 2 h. After standing overnight the solvent was evaporated in vacuo and the residue was treated with ammonium hydroxide and extracted with diethyl ether. The organic phase was dried (K2CO3) and the solvent was evaporated affording ethyl 4-(2-naphtylmethyl)-4-piperidinecarboxylate (3.2 g).

Provenance & Evidence