反应详情

96 mmol (1.6 equivalents) of MnO2 are added at room temperature under an inert atmosphere to a suspension of 60.4 mmol of the compound obtained in Step C in 360 ml of toluene. After 6 hours' reaction at 80° C., 0.6 equivalent of MnO2 is added to the reaction mixture, followed six hours later by 0.6 equivalent of MnO2. The reaction mixture is then filtered while hot over Celite and rinsed with toluene. After 12 hours at room temperature, the filtrate precipitates. Filtration of the precipitate followed by rinsing with toluene and then with pentane enables 8.65 g of the expected product to be isolated.

1. customAfter 6 hours' reaction at 80° C.
2. filtrationThe reaction mixture is then filtered while hot over Celite
3. washrinsed with toluene
4. customthe filtrate precipitates
5. filtrationFiltration of the precipitate
6. washby rinsing with toluene
7. customto be isolated