Ethyl (E)-3-[5,6-dimethoxy-3-(4-methoxyphenoxy)-benzo[b]thiophen-2-yl]-propenoat → Ethyl 3-[5,6-dimethoxy-3-(4-methoxyphenoxy)-benzo[b]thiophen-2-yl]-propanoate

Participants

Reaction Steps

A solution containing 0.8 mmol of the product obtained in Example 9 in 20 ml of methanol, and 0.2 g of 10% Pd/C is maintained at 40° C. for 24 hours under a stream of hydrogen. Filtration and concentration under reduced pressure and chromatography over silica gel (cyclohexane/ethyl acetate: 80/20) enable the expected product to be isolated.

Provenance & Evidence