Sodium borohydride → (5,6-Dimethoxy-3-(4-methyloxyphenoxy)-benzo[b]thiophen-2-yl)methanol

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Reaction Steps

26 mmol of NaBH4 are added at room temperature to a solution of 24 mmol of the compound obtained in Step E of Example 1 in 100 ml of methanol. After 2 hours' reaction, one equivalent of NaBH4 is added to the reaction mixture. After 12 hours' reaction, the solution is concentrated and then diluted with ethyl acetate, washed with a 1N HCl solution, then with water and then with a saturated NaCl solution, subsequently dried over calcium sulphate, filtered and concentrated under reduced pressure. Chromatography over silica gel (dichloromethane/ethyl acetate: 95/5) enables 6.07 g of the expected product to be isolated.

Provenance & Evidence