(E)-1-[3-(4-hydroxy-3-methoxyphenyl)-2-propenyl]-4-(4-phenoxyphenyl)piperidine → 4-(4-Phenoxyphenyl)-1-[3-(2,3,4-trimethoxyphenyl)-2-propenyl]piperidine

HRID 1004130Notes

Reaction equation

HRID 1004130 reaction equation
OC1C=CC(/C=C/C[N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)=CC=1OC.[CH3:32][O:33][C:34]1[C:43]([O:44][CH3:45])=[C:42]([O:46][CH3:47])[CH:41]=[CH:40][C:35]=1[CH:36]=[CH:37][CH2:38]Br>>[O:23]([C:20]1[CH:21]=[CH:22][C:17]([CH:14]2[CH2:15][CH2:16][N:11]([CH2:38][CH:37]=[CH:36][C:35]3[CH:40]=[CH:41][C:42]([O:46][CH3:47])=[C:43]([O:44][CH3:45])[C:34]=3[O:33][CH3:32])[CH2:12][CH2:13]2)=[CH:18][CH:19]=1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 18412177(E)-1-[3-(4-hydroxy-3-methoxyphenyl)-2-propenyl]-4-(4-phenoxyphenyl)piperidineHCID 54290809(2,3,4-Trimethoxy)cinnamyl bromide

Product 1

HCID 544367994-(4-Phenoxyphenyl)-1-[3-(2,3,4-trimethoxyphenyl)-2-propenyl]piperidine

Procedure

The same procedure was followed as in Example 11 using the compound (9) synthesized in Example 2 and (2,3,4-trimethoxy)cinnamyl bromide to produce the above.

Workup

  1. customto produce the above

Sources & evidence

ORD record
ord-1f6ff40edcfd40009dc78893dca1d4c0
Source dataset
uspto-grants-2000_04
Patent number
US06048876

Reaction notes

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