2-(Bromomethyl)-1-benzofuran → 1-(Benzofuran-2-yl)methyl-4-(4-phenoxyphenyl)piperidine
Reaction equation
OC1C=CC(/C=C/C[N:11]2[CH2:16][CH2:15][CH:14]([C:17]3[CH:22]=[CH:21][C:20]([O:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[CH:19][CH:18]=3)[CH2:13][CH2:12]2)=CC=1OC.Br[CH2:33][C:34]1[O:35][C:36]2[CH:42]=[CH:41][CH:40]=[CH:39][C:37]=2[CH:38]=1>>[O:35]1[C:36]2[CH:42]=[CH:41][CH:40]=[CH:39][C:37]=2[CH:38]=[C:34]1[CH2:33][N:11]1[CH2:16][CH2:15][CH:14]([C:17]2[CH:22]=[CH:21][C:20]([O:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[CH:19][CH:18]=2)[CH2:13][CH2:12]1Participants
3
Procedure
The same procedure was followed as in Example 11 using the compound (9) synthesized in Example 2 and 2-bromomethylbenzofuran to produce the above.
Workup
- customto produce the above
Sources & evidence
- ORD record
- ord-d9d45af8aa9c46fbbc4039c569ef1a41
- Source dataset
- uspto-grants-2000_04
- Patent number
- US06048876
Reaction notes
Loading…