1-(Bromomethyl)-4-chlorobenzene → HCID 21264569, compound

HRID 1004149Notes

Reaction equation

HRID 1004149 reaction equation
Cl.[NH:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18]Br)=[CH:16][CH:15]=1>>[Cl:13][C:14]1[CH:21]=[CH:20][C:17]([CH2:18][N:2]2[CH:6]=[CH:5][N:4]=[C:3]2[CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:16][CH:15]=1

Participants

3

Reactant 2

HCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 21264564HCID 21264564, compound

Product 1

HCID 21264569HCID 21264569, compoundYield 47.9%

Procedure

1.07 g of ethyl imidazol-2-ylaceate hydrochloride and 1.69 g of 4-chlorobenzyl bromide were subjected to an alkylation reaction to obtain 0.75 g of ethyl 1-(4-chlorobenzyl)imidazol-2-ylacetate.

Sources & evidence

ORD record
ord-223ddf677cec4494bbfcc1c951469db2
Source dataset
uspto-grants-2000_04
Patent number
US06048884

Reaction notes

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