HCID 23434124, compound → HCID 23434089, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 3-(2,5-dichloro-3-thienyl)propanoic acid (0.225 g) in Et2O (5 mL) was added 1.05M MeLi in Et2O (2.0 mL) at 0° C. under nitrogen. After stirring at 0° C. for 30 minutes, the mixture was warmed to room temperature and stirred for 1 hour. The reaction was quenched by the addition of phosphate buffer solution (pH=7), and the resulting mixture was extracted with Et2O (30 mL). The organic layer was washed with water, brine, dried over MgSO4, and concentrated in vacuo. Chromatographic purification of the residue eluting with hexane-ethyl acetate (4:1) to give the title compound (0.173 g).

Provenance & Evidence