Acetic Acid → HCID 53777669, compound

HRID 1004197Notes

Reaction equation

HRID 1004197 reaction equation
[NH2:1][CH:2]([CH2:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][N:17]([C:19]2[O:20][C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=3[N:23]=2)[CH3:18])=[CH:10][CH:9]=1)[C:3]([O:5][CH3:6])=[O:4].C(O)(=O)C.[N:32](OCCC(C)C)=O>C(Cl)(Cl)Cl>[O:20]1[C:21]2[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=2[N:23]=[C:19]1[N:17]([CH2:16][CH2:15][O:14][C:11]1[CH:10]=[CH:9][C:8]([CH2:7][C:2](=[N+:1]=[N-:32])[C:3]([O:5][CH3:6])=[O:4])=[CH:13][CH:12]=1)[CH3:18]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 8053Isoamyl NitriteHCID 10499318HCID 10499318, compound

Product 1

HCID 53777669HCID 53777669, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A mixture of methyl 2-amino-3-[4-[2-[N-(2-benzoxazolyl)-N-methylamino]ethoxy]phenyl]propanoate (5.00 g), acetic acid (4.4 mL) and chloroform (160 mL) was treated dropwise with isoamyl nitrite (3.2 mL). The mixture was heated at reflux for 1.5 hrs, cooled, diluted with chloroform (200 mL) and washed successively with dilute hydrochloric acid (200 mL), water (2×200 mL) and brine (200 mL). The chloroform solution was dried over MgSO4, evaporated and the residue chromatographed on silica gel using 3% ethyl acetate in dichloromethane as eluent to afford the title compound, a gum.

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 1.5 hrs
  3. temperaturecooled
  4. washwashed successively with dilute hydrochloric acid (200 mL), water (2×200 mL) and brine (200 mL)
  5. dry with materialThe chloroform solution was dried over MgSO4
  6. customevaporated
  7. customthe residue chromatographed on silica gel using 3% ethyl acetate in dichloromethane as eluent

Sources & evidence

ORD record
ord-f3ecc2ee94ab4c91a0ca438f56edef85
Source dataset
uspto-grants-2000_04
Patent number
US06048883

Reaction notes

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