反应详情

Using the procedure of Example 1, Step A, the N-alkylation reaction of 346.6 mg (1.72 mmol) of 6-nitro-1H-indolyl-3-acetonitrile (13) from Example 2, Step C with 0.3 ml (2.44 mmol) of trimethylacetyl chloride and 70.8 mg (1.77 mmol) of NaH (60% dispersion in oil) as a base in 8 ml of DMF yielded after chromatographic purification, 287.7 mg (43.2%) of [1-(2,2-dimethyl-propionyl)-6-nitro-1H-indol-3-yl]-acetonitrile (18) as a yellow oil.

1. customyielded
2. customafter chromatographic purification, 287.7 mg (43.2%) of [1-(2,2-dimethyl-propionyl)-6-nitro-1H-indol-3-yl]-acetonitrile (18) as a yellow oil