HCID 18794872, compound → HCID 9886464, compound

Participants

Reaction Steps

Using the procedure of Example 1, Step F, the N-deprotection reaction of 1.3 g (2.76 mmol) of 3-[1-(2,2-dimethyl-propionyl)-6-nitro-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione (20) from Step D above with 4.3 ml (6.88 mmol) of a 1.6 molar solution of NaOCH3 in 65 ml of methanol yielded 300.6 mg (28.1%) of 3-(1-methyl-1H-indol-3-yl)-4-(6-nitro-1H-indol-3-yl)-pyrrole-2,5-dione (III) as a red solid after crystallization from ethyl acetate and hexane. mp>260° C. MS: (M+), m/z 386.

Provenance & Evidence