HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl (2-(1,8-naphthyridin-2-yl)ethyl)carbamate → tert-Butyl (2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl (2-(1,8-naphthyridin-2-yl)ethyl)carbamate | HCID 53952251 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl (2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)carbamate | HCID 54085210 | — |
Reaction Steps
A mixture of 10-5 (5.0 g, 20.4 mmol), 10% Pd/C (2.5 g), and EtOH (200 mL) was stirred under a balloon of hydrogen for 15 h. The mixture was filtered, and the filtrate concentrated to give 10-6 as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06048861 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-bb7b1b943e2641dd9bafcde67ba18743 |
| Source note | uspto-grants-2000_04 |