HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Hydroxide → tert-Butyl 3-(1,8-naphthyridin-2-yl)propylcarbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 3-Pyridinecarboxaldehyde, 2-amino- | HCID 737633 | — |
| Reactant | tert-Butyl (4-oxopentyl)carbamate | HCID 21478928 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl 3-(1,8-naphthyridin-2-yl)propylcarbamate | HCID 11369698 | — |
Reaction Steps
A mixture of 11-4 (5.0 g, 24.8 mmol), 1-3, 2-amino-3-formylpyridine (3.6 g, 29.8 mmol) and 20% KOH (1 ml) in absolute ethanol (100 mL) was heated at reflux for 8 h. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 70:28:2 chloroform/ethyl acetate/methanol) to give 11-6 as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06048861 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-746c9ca4a7144c77aa2025c7e1cd2bb1 |
| Source note | uspto-grants-2000_04 |