HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 3-(1,2,3,4,6,7,8,9-Octahydro-benzo[b][1,8]naphthyridin-8-yl)-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-(1,2,3,4,6,7,8,9-Octahydro-benzo[b]-[1,8]naphthyridin-8-yl)-propionic acid ethyl ester | HCID 54421578 | — |
| Solvent | Oxolane--water (1/1) | HCID 21881883 | — |
| Product | 3-(1,2,3,4,6,7,8,9-Octahydro-benzo[b][1,8]naphthyridin-8-yl)-propionic acid | HCID 22678162 | — |
Reaction Steps
A solution of 14-3 (0.180 g, 0.62 mmol) and NaOH (1.24 mL of a 1N soln, 1.24 mmol) in THF/H2O (5 mL./5 mL) was stirred at room temperature for 12 h. The solution was concentrated. The residue was triturated with Et2O to give 14-4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06048861 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-86550657669848fcae77c2ad6c86e78b |
| Source note | uspto-grants-2000_04 |