Sodium Hydroxide → HCID 10202171, compound

HRID 1004282Notes

Reaction equation

HRID 1004282 reaction equation
C[O:2][C:3](=[O:32])[CH2:4][CH:5]([C:22]1[CH:23]=[N:24][C:25]2[C:30]([CH:31]=1)=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:6][CH2:7][CH2:8][CH2:9][NH:10][CH2:11][C:12]1[CH:21]=[CH:20][C:19]2[CH2:18][CH2:17][CH2:16][NH:15][C:14]=2[N:13]=1.[OH-].[Na+]>CCO>[N:13]1[C:14]2[NH:15][CH2:16][CH2:17][CH2:18][C:19]=2[CH:20]=[CH:21][C:12]=1[CH2:11][NH:10][CH2:9][CH2:8][CH2:7][CH2:6][CH:5]([C:22]1[CH:23]=[N:24][C:25]2[C:30]([CH:31]=1)=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH2:4][C:3]([OH:32])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 54146973HCID 54146973, compound

Product 1

HCID 10202171HCID 10202171, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 21-7 (0.8255 mmol) in EtOH (5 mL) was added 1N NaOH (1.0 ml, 1.0 mmol). After stirring for 1 hour, the solvents were evaporated and the residue was chromatographed (silica gel, 20:10:1:1 followed by 15:10:1:1 ethyl acetate/EtOH/water NH4OH) to give 21-8 as a white solid.

Workup

  1. customthe solvents were evaporated
  2. customthe residue was chromatographed (silica gel, 20:10:1:1 followed by 15:10:1:1 ethyl acetate/EtOH/water NH4OH)

Sources & evidence

ORD record
ord-e87cf0c82d324b3ba32c34c3f0a3ec1d
Source dataset
uspto-grants-2000_04
Patent number
US06048861

Reaction notes

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