反应详情

A solution of 2-trifluoromethylphenylacetic acid (5.0 g) in methanol (30 ml) containing 5 drops of concentrated sulphuric acid was heated at reflux for 2 hours. The reaction mixture was concentrated, diluted with ethyl acetate (100 ml), washed with 1N sodium hydroxide (25 ml) then with brine (25 ml), dried over magnesium sulphate and evaporated to give the title compound (5.04 g) as a colourless oil.

1. temperaturewas heated
2. temperatureat reflux for 2 hours
3. concentrationThe reaction mixture was concentrated
4. additiondiluted with ethyl acetate (100 ml)
5. washwashed with 1N sodium hydroxide (25 ml)
6. dry with materialwith brine (25 ml), dried over magnesium sulphate
7. customevaporated