HCID 18794886, compound → HCID 18794892, compound

HRID 1004337Notes

Reaction equation

HRID 1004337 reaction equation
C(OC(C1OC(CC(C([NH:22][CH2:23][C:24]2[CH:33]=[CH:32][C:31]3[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=3)[CH:25]=2)C)C(OC(C)(C)C)=O)=CC=1)=O)C.[Si:34]([O:41][CH2:42][CH:43]([CH2:47][C:48]1[O:49][C:50]([C:53](=[O:61])[NH:54][C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=2)=[CH:51][CH:52]=1)[CH:44](O)[CH3:45])([C:37]([CH3:40])([CH3:39])[CH3:38])([CH3:36])[CH3:35]>>[CH:25]1[C:26]2[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:32]=[CH:33][C:24]=1[CH2:23][NH:22][CH:44]([CH3:45])[CH:43]([CH2:42][O:41][Si:34]([C:37]([CH3:38])([CH3:39])[CH3:40])([CH3:36])[CH3:35])[CH2:47][C:48]1[O:49][C:50]([C:53](=[O:61])[NH:54][C:55]2[CH:56]=[CH:57][CH:58]=[CH:59][CH:60]=2)=[CH:51][CH:52]=1

Participants

3

Reactant 2

HCID 18794886HCID 18794886, compoundHCID 54102143HCID 54102143, compound

Product 1

HCID 18794892HCID 18794892, compound

Procedure

The title compound was prepared by the same reactions as in Reference Example 1(3) and (4) by using (2RS,3SR)-3-(tert-butyldimethylsilyloxymethyl)-2-hydroxy-4-{5-(phenylcarbamoyl)-2-furyl}butane instead of tert-butyl (2RS,3SR)-2-{5-(ethoxycarbonyl)-2-furylmethyl}-3-hydroxybutanoate used as the starting material in Reference Example 1(3).

Sources & evidence

ORD record
ord-2ab5ea2920f14f4e95fe5ffe4db57764
Source dataset
uspto-grants-2000_04
Patent number
US06048894

Reaction notes

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