Ammonium Chloride → HCID 178488155, compound

HRID 1004404Notes

Reaction equation

HRID 1004404 reaction equation
[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[Cl-].[Mg+2].[Cl-].[Cl-].[NH4+:29]>N>[CH3:1][C:2]1[CH:3]=[N:4][C:5]([CH2:11][S+:12]([O-:24])[C:13]2[NH:14][C:15]3[CH:16]=[CH:17][C:18]([O:22][CH3:23])=[CH:19][C:20]=3[N:21]=2)=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].[NH3:29]

Participants

5

Reactant 3

HCID 25517Ammonium ChlorideHCID 5360315Magnesium ChlorideHCID 178488147HCID 178488147, compound2×

Product 1

HCID 178488155HCID 178488155, compound

Reagents, catalysts & solvents 1

HCID 222AmmoniaSolvent2×

Procedure

In the process of the invention, it is preferred to pre-form a solution of omeprazole in concentrated ammonia, and to add this to a pre-formed aqueous solution of magnesium salt (preferably magnesium chloride) and ammonium salt (preferably ammonium chloride), so that the magnesium ion is in excess during the mixing procedure. However, other orders of addition can be used if the process is conducted carefully, such as mixing the omeprazole, ammonia and ammonium salt first, and adding the magnesium salt to this mixture, or, less desirably, pre-mixing the magnesium salt and ammonium salt, and adding this mixture to pre-formed omeprazole/ammonia solution.

Workup

  1. additionHowever, other orders of addition
  2. additionadding this mixture

Sources & evidence

ORD record
ord-138450476fed447f9ca63b57449a9eca
Source dataset
uspto-grants-2000_04
Patent number
US06048981

Reaction notes

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