HCID 5073097, compound → HCID 70263997, compound

Participants

Reaction Steps

A mixture of N-(2-hydroxy-2-phenyl-ethyl)-2-methyl-propanamide (15.0 g, 72 mmol), prepared in the previous step, and pyridinium chlorochromate (23.7 g, 110 mmol) in 300 ml of methylene chloride was stirred at room temperature for 5 hours. The reaction was filtered and the filtrate concentrated under reduced pressure to give a dark residue. Chromatography of the residue on silica gel (230-400 mesh) using ethyl acetate-methylene chloride as the eluent gave N-(2-oxo-phenyl-ethyl)-2-methyl-propanamide (6.07 g, 41%) as a light green solid, mp 88-93° C.

Provenance & Evidence