Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | L-N-Cbz-3-N-Boc-Amino-alanine | HCID 2756240 | — |
| 촉매 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | (S)-Methyl 2-N-Cbz-3-N-Boc-propanoate | HCID 10831821 | — |
반응 단계
The product (0.867 g) obtained in the above (2) is dissolved in dichloromethane (15 ml), and thereto are added methanol (1.5 ml), 4-dimethylaminopyridine (34 mg) and WSC.HCl (0.633 g) under ice-cooling. The mixture is stirred under ice-cooling for two hours, and then stirred at room temperature for 12 hours. The mixture is concentrated under reduced pressure to the volume of about 5 ml, and the residue is poured into water.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06048854 |
| 출처 데이터셋 | uspto-grants-2000_04 |
| ORD ID | ord-dbaec3730ab5487cb2472885e180c77d |
| 출처 메모 | uspto-grants-2000_04 |