HCID 57284408, compound → HCID 70181628, compound

HRID 1004504Notes

Reaction equation

HRID 1004504 reaction equation
[CH3:1][O:2][C:3](=[O:40])[C@@H:4]([NH:29]C(OCC1C=CC=CC=1)=O)[CH2:5][NH:6][C:7](=[O:28])[CH2:8][CH2:9][NH:10][C:11](=[O:27])[CH2:12][CH2:13][CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:16][CH2:15]1>C(O)C.[C].[Pd]>[CH3:1][O:2][C:3](=[O:40])[C@@H:4]([NH2:29])[CH2:5][NH:6][C:7](=[O:28])[CH2:8][CH2:9][NH:10][C:11](=[O:27])[CH2:12][CH2:13][CH:14]1[CH2:15][CH2:16][N:17]([C:20]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:21])[CH2:18][CH2:19]1

Participants

4

Reactant 1

HCID 57284408HCID 57284408, compound

Product 1

HCID 70181628HCID 70181628, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 702EthanolSolvent

Procedure

The compound (0.578 g) obtained in the above (4) is dissolved in ethanol (15 ml), and thereto is added 10% palladium-carbon (50% wet, 0.4 g), and the mixture is stirred at room temperature for four hours under hydrogen atmosphere. The insoluble materials are removed by filtration, and the filtrate is concentrated under reduced pressure to give the title compound (398 mg).

Workup

  1. customThe insoluble materials are removed by filtration
  2. concentrationthe filtrate is concentrated under reduced pressure

Sources & evidence

ORD record
ord-6f219bec7289468ea72a301d167e6878
Source dataset
uspto-grants-2000_04
Patent number
US06048854

Reaction notes

Loading…