Trifluoroacetic acid → HCID 86755327, compound

Participants

Reaction Steps

To a solution of 4-[[[3,5-bis(acetylmethylamino)-2,4,6-triiodophenyl]carbonyl]amino]-benzenepentadecanoic acid, 1,1-dimethylethyl ester XIe of Example 7b (30 mg, 0.3 mmol) in anisole (1 mL), was added trifluoroacetic acid (10 mL) and the mixture stirred at RT overnight (15 h). The solvents were removed in vacuo, and the residue crystalized from ethyl acetate to furnish pure XIIe as a white amorphous solid (205 mg, yield 70%, purity >98%). Additional product (35 mg, purity 96%) was obtained from the mother liquor for a total yield of 81%.

Provenance & Evidence