Pyridine → 2-Fluoro-4-propylbenzoyl chloride

Participants

Reaction Steps

First, 1.1 g (6.1 mmol) of 2-fluoro-4-propylbenzoic acid was mixed with 1.1 g (9.1 mmol) of thionyl chloride, 0.1 ml of pyridine, and 3 ml of toluene, and reacted at 80° C. for 2 hours. Excess amount of thionyl chloride and toluene were distilled off at a reduced pressure to obtain a crude 2-fluoro-4-propylbenzoyl chloride.

Provenance & Evidence