Pyridine → HCID 178455785, compound

HRID 1004534Notes

Reaction equation

HRID 1004534 reaction equation
[CH2:1]([C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([OH:11])=O)[CH2:5][CH2:4]1)[CH3:2].S(Cl)([Cl:14])=O.N1C=CC=CC=1>C1(C)C=CC=CC=1>[CH2:1]([C@H:3]1[CH2:8][CH2:7][C@H:6]([C:9]([Cl:14])=[O:11])[CH2:5][CH2:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 178455790HCID 178455790, compound

Product 1

HCID 178455785HCID 178455785, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

First, 1.0 g (6.1 nmmol) of trans-4-ethylcyclohexane carboxylic acid was mixed with 1.1 g (9.2 mmol) of thionyl chloride, 0.1 ml of pyridine, and 3 ml of toluene, and reacted at 60° C. for hours. Excess amount of thionyl chloride and toluene were distilled off at a reduced pressure to obtain a crude trans-4-ethylcyclohexylcarbonylchloride.

Workup

  1. customreacted at 60° C. for hours
  2. distillationExcess amount of thionyl chloride and toluene were distilled off at a reduced pressure

Sources & evidence

ORD record
ord-02abf91f3408426d83df14884b2a80a2
Source dataset
uspto-grants-2000_04
Patent number
US06051288

Reaction notes

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