Pyridine → HCID 178444411, compound

HRID 1004536Notes

Reaction equation

HRID 1004536 reaction equation
[F:1][C:2]1[CH:10]=[C:9]([CH2:11][CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:15][CH2:14]2)[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:26])=O.N1C=CC=CC=1>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:10]=[C:9]([CH2:11][CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:15][CH2:14]2)[CH:8]=[CH:7][C:3]=1[C:4]([Cl:26])=[O:5]

Participants

5

Reactant 3

HCID 1049PyridineHCID 24386Thionyl ChlorideHCID 178444413HCID 178444413, compound

Product 1

HCID 178444411HCID 178444411, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

First, 2.1 g (6.4 mmol) of 2-fluoro-4-(2-(trans-4-pentyl-cyclohexyl)ethyl)benzoic acid was mixed with 1.1 g (9.6 mmol) of thionyl chloride, 0.1 ml of pyridine, and 3 ml of toluene, and reacted at 80° C. for 3 hours. Excess amount of thionyl chloride and toluene were distilled off at a reduced pressure to obtain a crude 2-fluoro-4-(2-(trans-4-pentyl-cyclohexyl)ethyl)benzoyl chloride.

Workup

  1. customreacted at 80° C. for 3 hours
  2. distillationExcess amount of thionyl chloride and toluene were distilled off at a reduced pressure

Sources & evidence

ORD record
ord-545a5971c4bc408f82b94440853d7457
Source dataset
uspto-grants-2000_04
Patent number
US06051288

Reaction notes

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