Hydrochloric Acid → HCID 18792546, compound

Participants

Reaction Conditions

Reaction Steps

In a one liter reaction flask were dissolved 220.0 g of resorcinol in 300 ml of de-mineralized water. To this solution 18.22 g of 2,6-bis(hydroxymethyl)-3,4-dimethylphenol was added and stirred until it dissolved. 5 ml of concentrated hydrochloric acid was then added and the reaction mixture stirred at ambient temperature for about 15 hours. The mixture was then chilled to -12° C. and the crystalline precipitate isolated in a chilled Buchner funnel. The crude product was suspended in 300 ml of de-mineralized water and re-isolated by vacuum filtration. The wet solid was first partially air dried and then vacuum oven dried at 60° C. to yield 20.4 g product having a purity of about 95% as determined by HPLC.

Provenance & Evidence