Sodium Hydroxide → HCID 15454675, compound

Participants

Reaction Steps

The title compound (0.95 g, 63%) was prepared by the general procedure using, 6-fluoro-5-(piperidin-1-yl)-2-mercapto-1H-benzimidazole (0.70 g, 2.8 mmol) (obtained in preparation 3), 4-(piperidin-1-yl)-3 )-methyl-2-chloromethylpyridine hydrochloride (0.91 g, 3.5 mmol), sodium hydroxide (0.30 g, , 7.7 mmol) and ethanol (15 mL). mp 161-162° C.; IR (KBr) 3430, 1581, 1429 cm-1 ; 1H NMR (CDCl3) δ 1.60 (m, 4H, 2×CH2), 1.74 (m, 8H, 2×(CH2)2), 2.30 (s, 3)H, CH3), 3.00 (m, 8H, 2×N(CH2)2), 4.32 (s, 2H, SCH2), 6.82 (d, J=5.4 Hz, 1H), 7.12 (d, J=7.7 Hz, 1H), 7.24 (d, J=12.1 Hz, 1H), 8.28 (d, J=5.5 Hz, 1H); Mass (m/z) 439 (M+).

Provenance & Evidence