Hydrazine → HCID 53785282, compound

HRID 1004603Notes

Reaction equation

HRID 1004603 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1([OH:13])[CH:11]2[CH2:12][N:8]([CH2:9][CH2:10]2)[CH2:7]1)C.[NH2:15][NH2:16]>CO>[OH:13][C:6]1([CH2:5][C:4]([NH:15][NH2:16])=[O:3])[CH:11]2[CH2:12][N:8]([CH2:9][CH2:10]2)[CH2:7]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 53800227HCID 53800227, compound

Product 1

HCID 53785282HCID 53785282, compoundYield 107%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the product of step (a) (1.12 g, 0.0056 moles) in methanol (20 ml) at room temperature was added anhydrous hydrazine (1.76 ml, 0.056 moles) and the mixture was stirred overnight. The mixture was concentrated in vacuo and azeotroped twice with toluene (100 ml) by heating to reflux in an apparatus fitted with a Dean-Stark trap to give the subtitle compound (1.11 g).

Workup

  1. concentrationThe mixture was concentrated in vacuo
  2. customazeotroped twice with toluene (100 ml)
  3. temperatureby heating
  4. temperatureto reflux in an apparatus
  5. customfitted with a Dean-Stark trap

Sources & evidence

ORD record
ord-2722b640edb440c58e25727cdc57e91e
Source dataset
uspto-grants-2000_04
Patent number
US06051581

Reaction notes

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