化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl Ether → (6-Thien-2-ylpyrid-3-yl)methanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 6-(Thiophen-2-Yl)Pyridine-3-Carboxylic Acid | HCID 15411144 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | (6-Thien-2-ylpyrid-3-yl)methanol | HCID 15411145 | — |
反応手順
To a solution of 2-(thien-2-yl)-5-pyridinecarboxylic acid (0.333 g, 1.60 mmol) in THF (5 mL) at 0° C. is added 1.0 M lithium aluminum hydride in diethyl ether (1.60 mL, 1.60 mmol) over 10 minutes. The reaction is allowed to stir at ambient temperature for 3 hours, cooled to 0° C., and water (0.10 mL), 4 N aq. NaOH (0.10 mL), and water (0.30 mL) are added sequentially. The reaction is filtered through a pad of Celite and the filtrate is evaporated in vacuo. The residue is purified by chromatography to afford the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06051574 |
| 出典データセット | uspto-grants-2000_04 |
| ORD ID | ord-a548706e0a3147e19f36697c38d7dffa |
| 出典メモ | uspto-grants-2000_04 |