Imidazole → HCID 53726250, compound

Participants

Reaction Steps

Imidazole (554 mg, 8.14 mmol) and tert-butyldimethylsilyl chloride (1.13 g, 7.52 mmol) were added to a solution of the compound (1.61 g, 6.26 mmol) prepared in Example 3 in N,N-dimethylformamide (7 ml) at room temperature in an argon atmosphere. After stirring overnight at this temperature, the mixture was diluted with ethyl acetate. The organic layer was washed with saturated aqueous solution of potassium hydrogensulfate and saturated brine in this order, and dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure and the residue was purified by silica gel chromatography (hexane/ethyl acetate=20/1) to obtain 2.157 g (yield 93%) of the title compound as a colorless oily substance.

Provenance & Evidence