HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18793505, compound → HCID 18793518, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18793505 | HCID 18793505 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ammonia methanol | HCID 21705897 | — |
| Product | HCID 18793518 | HCID 18793518 | 98.8% |
Reaction Steps
A mixture of intermediate 9 (0.0129 mol) in CH3OH/NH3 (100 ml) was hydrogenated at RT with Raney Nickel (3 g) as a catalyst. After uptake of H2, the catalyst was filtered off and the filtrate was evaporated, yielding 3.66 g (98%) of (±)-4-(difluoromethoxy)-β-methyl-3-[(tetrahydro-3-furanyl)oxy]benzeneethanamine (intermediate 10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06051718 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-07cb66af9dd34c99bd36454cd869e7be |
| Source note | uspto-grants-2000_04 |