HCID 18793519, compound → HCID 18793513, compound

Participants

Reaction Steps

A mixture of intermediate 21 (0.0117 mol) in NH3 /CH3OH (60 ml) was hydrogenated at RT with Raney Nickel (2 g) as a catalyst. After uptake of H2, the catalyst was filtered off and the filtrate was evaporated. The residue was treated with a 10% aqueous HCl solution, and this mixture was extracted with ethylacetate. The layers were separated. The aqueous phase was basified, then extracted with ethylacetate. The separated organic layer was dried, filtered, and the solvent was evaporated, yielding 2.71 g (75%) of (±)-N-[2-[3-(cyclopentyloxy)-4-methoxyphenyl]propyl]-1,2-ethanediamine (intermediate 22).

Provenance & Evidence