Oxalyl chloride → 2,6-Difluorobenzoyl isocyanate

Participants

Reaction Conditions

Reaction Steps

0.49 g (3.1 mmol) of 2,6-difluorobenzamide and 0.43 g (3.4 mmol, 1.1 eq) of oxalyl chloride were added to 10 ml of 1,2-dichloroethane and then the mixture was stirred for 8 hours at 100° C. The reaction solution was cooled down to room temperature. The reaction solvent and excessive oxalyl chloride were removed by distillation under reduced pressure to obtain 2,6-difluorobenzoyl isocyanate in an oily state. 10 ml of fresh 1,2-dichloroethane and 0.85 g (3.1 mmol) of 2-bromo-4-chloro-5-trifluoromethyl aniline were successively added thereto, reacted for 2 hours and filtered to obtain 0.82 g (Yield 76%) of the title compound as a solid.

Provenance & Evidence