HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methylbenzofuran → 5-(Bromomethyl)benzofuran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methylbenzofuran | HCID 33103 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 5-Methylbenzo(b)thiophene | HCID 84346 | — |
| Reactant | 5-(Bromomethyl)benzo[b]thiophene | HCID 11160498 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 5-(Bromomethyl)benzofuran | HCID 22128522 | — |
Reaction Steps
By brominating 5-methyl-benzo[b]furan[Synth. Commun. 19, 257(1989)] with N-bromosuccinimide in carbon tetrachloride in an analogous manner to the procedure for the preparation of 5-bromomethyl-benzo[b]thiophene [J. Med. Chem. 34(1), 65(1991)] from 5-methyl-benzo[b]thiophene there was obtained 5-bromomethyl-benzo[b]furan as a light yellow solid; MS: 210, 212 (M)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06051712 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-21137035b803423d9f2fc489f1a767c3 |
| Source note | uspto-grants-2000_04 |