HuagongsheHuagongshe Chemistry Print Report · For research reference only
Borane → HCID 22127280, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Borane | HCID 6331 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1-Methyl-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine | HCID 78745 | — |
| Product | HCID 22127280 | HCID 22127280 | — |
Reaction Steps
In an analogous manner to that described in Example 1(c), from 4-(4-chloro-phenyl)-1-methyl-1,2,3,6-tetrahydropyridine [U.S. Pat. No. 3,320,265] by hydroboration using borane in tetrahydrofuran there was obtained (3RS,4RS)-4-(4-chloro-phenyl)-1-methyl-piperidin-3-ol which, after recrystallization from a mixture of methylene chloride and hexane, formed colourless crystals of m.p.: 99-100° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06051712 |
| Source dataset | uspto-grants-2000_04 |
| ORD ID | ord-2faba196a32d427297e99e54c0eb0ea0 |
| Source note | uspto-grants-2000_04 |