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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1004963Generated: October 30, 2026

Ethanol, 2-(trimethylsilyl)-, carbamate → HCID 22128795, compound

https://huagongshe.com/reaction/1004963

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthanol, 2-(trimethylsilyl)-, carbamateHCID 18399—
ReactantTetrabutylammonium FluorideHCID 2724141—
ReactantHCID 54538119HCID 54538119—
SolventTetrahydrofuranHCID 8028—
ProductHCID 22128795HCID 22128795—

Reaction Steps

From β-trimethylsilylethyl (3RS,4RS)-4-(4-fluorophenyl)-3-[4-[2-(2-trimethylsilyl-ethoxymethoxy)-benzyloxy]-naphthalen-2-ylmethoxy]-piperidine-1-carboxylate by cleaving the β-trimethylsilylethyl carbamate with tetrabutylammonium fluoride in tetrahydrofuran in analogy to the procedure described in Example 5 there was obtained (3RS,4RS)-4-(4-fluorophenyl)-3-[4-[2-(2-trimethylsilyl-ethoxymethoxy)-benzyloxy]-naphthalen-2-ylmethoxy]-piperidine as a rose coloured oil; MS: 588 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06051712
Source datasetuspto-grants-2000_04
ORD IDord-3e44ece9b64c4aee8b0dfb5845cf44ef
Source noteuspto-grants-2000_04