HRID1005002

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4148881

Lithium borohydride

BH4Li

HCID54179161

未命名化合物

PRODUCTS

产物

HCID54536116

未命名化合物

PROCEDURE

实验过程

In an analogous manner to that described in Example 22(e), by reducing tert-butyl (3RS,4RS)-3-(4-benzyloxy-naphthalen-2-ylmethoxy)-4-(3-methoxycarbonyl-phenyl)-piperidine-1-carboxylate with lithium borohydride there was obtained tert-butyl (3RS,4RS)-3-(4-benzyloxy-naphthalen-2-ylmethoxy)-4-(3-hydroxymethyl-phenyl)-piperidine-1-carboxylate as a colourless solid; MS: 554 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-f071ec7616a04d268d67ba38a739f03c
来源数据集: uspto-grants-2000_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06051712
来源说明: uspto-grants-2000_04

反应SMILES

[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[C:11]([CH2:19][O:20][CH:21]2[CH:26]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([C:33](OC)=[O:34])[CH:28]=3)[CH2:25][CH2:24][N:23]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:22]2)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[BH4-].[Li+]>>[CH2:1]([O:8][C:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[C:11]([CH2:19][O:20][CH:21]2[CH:26]([C:27]3[CH:32]=[CH:31][CH:30]=[C:29]([CH2:33][OH:34])[CH:28]=3)[CH2:25][CH2:24][N:23]([C:37]([O:39][C:40]([CH3:43])([CH3:42])[CH3:41])=[O:38])[CH2:22]2)[CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1