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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1005066Generated: October 26, 2026

2-Bromomethylnaphthalene → tert-butyl (3RS,4RS)-4-(4-allyloxy-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

https://huagongshe.com/reaction/1005066

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-BromomethylnaphthaleneHCID 70320—
ReactantTert-butyl 4-(4-allyloxyphenyl)-3-hydroxypiperidine-1-carboxylateHCID 54331732—
Producttert-butyl (3RS,4RS)-4-(4-allyloxy-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylateHCID 86604422—

Reaction Steps

In analogy to the procedure described in Example 3(c) by alkylating tert-butyl (3RS,4RS)-4-(4-allyloxy-phenyl)-3-hydroxy-piperidine-1-carboxylate with 2-bromomethylnaphthalene there was obtained tert-butyl (3RS,4RS)-4-(4-allyloxy-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate as a colourless oil; MS: 474 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06051712
Source datasetuspto-grants-2000_04
ORD IDord-3932c4e99c65439cbaad09208d6f2133
Source noteuspto-grants-2000_04