2-Chloromethyl-4-(beta-trimethylsilylethoxymethoxy)-naphthalene → tert-butyl (3RS,4RS)-3-[4-(2-trimethylsilanyl-ethoxymethoxy)-naphthalen-2-ylmethoxy]-4-[4-(2-trityloxy-ethyl)-phenyl]-piperidine-1-carboxylate

Participants

Role	Name	HCID	Charge
Reactant	2-Chloromethyl-4-(beta-trimethylsilylethoxymethoxy)-naphthalene	HCID 22126529	—
Reactant	tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(2-trityloxy-ethyl)-phenyl]-piperidine-1-carboxylate	HCID 86604448	—
Product	tert-butyl (3RS,4RS)-3-[4-(2-trimethylsilanyl-ethoxymethoxy)-naphthalen-2-ylmethoxy]-4-[4-(2-trityloxy-ethyl)-phenyl]-piperidine-1-carboxylate	HCID 54268675	—

Reaction Steps

(α) In an analogous manner to that described in Example 1 (g), by alkylating tert-butyl (3RS,4RS)-3-hydroxy-4-[4-(2-trityloxy-ethyl)-phenyl]-piperidine-1-carboxylate [Example 29 (t)] with 3-chloromethyl-1-(2-trimethylsilanyl-ethoxymethoxy)-naphthalene [Example 5 (c)] there was obtained tert-butyl (3RS,4RS)-3-[4-(2-trimethylsilanyl-ethoxymethoxy)-naphthalen-2-ylmethoxy]-4-[4-(2-trityloxy-ethyl)-phenyl]-piperidine-1-carboxylate.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06051712
Source dataset	uspto-grants-2000_04
ORD ID	ord-261792528c8b494daed49049e1e8f1d1
Source note	uspto-grants-2000_04