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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1005151Generated: October 29, 2026

6-(Bromomethyl)isoquinoline hydrobromide → tert-butyl (3RS,4RS)-4-[4-(3-benzyloxy-propoxy)-phenyl]-3-(isoquinolin-6-ylmethoxy)-piperidine-1-carboxylate

https://huagongshe.com/reaction/1005151

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-(Bromomethyl)isoquinoline hydrobromideHCID 22126816—
ReactantHCID 54071872HCID 54071872—
Producttert-butyl (3RS,4RS)-4-[4-(3-benzyloxy-propoxy)-phenyl]-3-(isoquinolin-6-ylmethoxy)-piperidine-1-carboxylateHCID 53901823—

Reaction Steps

By alkylating tert-butyl (3RS,4RS)-4-[4-(3-benzyloxy-propoxy)-phenyl]-3-hydroxy-piperidine-1-carboxylate [Example 86 (n)] with 6-bromomethyl-isoquinoline hydrobromide (Example 4) analogously to Example 1 (g) there was obtained tert-butyl (3RS,4RS)-4-[4-(3-benzyloxy-propoxy)-phenyl]-3-(isoquinolin-6-ylmethoxy)-piperidine-1-carboxylate as a colourless oil; MS: 583 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06051712
Source datasetuspto-grants-2000_04
ORD IDord-a56e60d78e5b4824aeb1ae3d08ddd8d4
Source noteuspto-grants-2000_04